conferone

Conferone is a natural sesquiterpene coumarin isolated from the roots of *Ferula badrakema*. It is primarily recognized for its potent chemosensitizing activity rather than direct cytotoxicity. In preclinical studies involving bladder cancer cell lines (such as 5637 cells), conferone has been shown to significantly enhance the cytotoxic effects of vincristine. Its mechanism of action involves the inhibition of P-glycoprotein (P-gp), an ATP-binding cassette transporter that facilitates the efflux of various chemotherapeutic drugs, thereby contributing to multidrug resistance (MDR). By blocking P-gp, conferone increases the intracellular accumulation and efficacy of co-administered drugs.

Other names

conferone