conjugated estrogens

Conjugated estrogens are a standardized mixture of estrogen sulfate salts, historically derived from pregnant mare urine, with estrone sulfate and equilin sulfate among the principal components. They are systemic estrogen-replacement agents that activate estrogen receptor alpha and estrogen receptor beta, altering estrogen-responsive gene transcription in reproductive tissues, bone, vasculature, and other organs. Pfizer markets conjugated estrogens as Premarin in oral, vaginal, and intravenous formulations. Labeled uses include menopausal vasomotor symptoms, vulvar and vaginal atrophy, hypoestrogenism due to hypogonadism, castration, or primary ovarian failure, prevention of postmenopausal osteoporosis, palliative treatment of selected metastatic breast cancer and advanced androgen-dependent prostate cancer, and short-term treatment of abnormal uterine bleeding with the intravenous formulation.

Brand names

Premarin

Other names

conjugated equine estrogensCEEequine conjugated estrogens