connexin43 antisense oligodeoxynucleotides

Connexin43 antisense oligodeoxynucleotides are synthetic, single-stranded DNA molecules (typically 30 deoxynucleotides, unmodified backbone) designed to bind specifically to the mRNA of the gap junction protein connexin43 (Cx43), thereby reducing its expression via RNase H-mediated degradation of the target mRNA[2][4][7]. They have been studied primarily for their ability to downregulate Cx43 after injury, which modulates inflammatory responses, reduces secondary damage, promotes tissue repair and axonal regeneration, and improves wound healing[1][2][3][4][7][9][11]. Applications include spinal cord injury, optic nerve injury, neuroinflammation, and skin wound repair, often delivered via hydrogels or scaffold-mediated platforms to enable sustained release at the target site[2][7][9]. Connexin43 antisense oligodeoxynucleotides do not affect pre-existing Cx43 protein, and their effects are transient unless sustained drug delivery approaches are used[4].

Other names

Connexin43 antisense DNAConnexin-43 antisense DNAConnexin 43 antisense DNAConnexin43 antisense oligonucleotideConnexin-43 antisense oligonucleotideConnexin 43 antisense oligonucleotide