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Consolidation #4
- Development stage
- Unknown
- Lead developer
- Yonsei University
- Modality
- Small Molecules
- Administration
- Intravenous, Oral
01
Overview
Consolidation #4 is a multi-agent chemotherapy regimen, specifically the VCPAD block, utilized in the treatment of newly diagnosed infant leukemia within risk-stratified clinical protocols. This regimen is part of a Phase 2 multicenter study led by Yonsei University aimed at improving survival rates in pediatric patients by eradicating minimal residual disease (MRD) following induction therapy. The regimen consists of a combination of five antineoplastic agents: vincristine, cyclophosphamide, cytarabine, daunorubicin, and dexamethasone. These drugs work synergistically through diverse mechanisms, including DNA alkylation, microtubule disruption, inhibition of DNA synthesis, and glucocorticoid-mediated apoptosis, to target high-risk leukemic cells and prevent relapse.
- Other names
- Consolidation 4Consolidation4Consolidation-4VCPADBlock 4Block4Block-4
02
Targets
PPAT (Amidophosphoribosyltransferase)TOP2A (DNA topoisomerase II)DHFR (Dihydrofolate reductase)DNA polymerase familyGR (Glucocorticoid receptor)DNATUBB (Tubulin (alpha and beta subunits))
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