control continuous peripheral nerve blocks-University of California, San Diego-phantom limb pain-residual limb pain

This refers to the control arm of a multicenter, randomized, triple-masked clinical trial conducted by the University of California, San Diego, investigating the prevention of phantom limb pain and residual limb pain following lower extremity amputation. The control intervention consists of a continuous peripheral nerve block (CPNB) using a low-concentration local anesthetic (either 0.1% bupivacaine or 0.2% ropivacaine) for the first 24 hours post-surgery, followed by a 6-day infusion of normal saline (placebo). This protocol is designed to provide standard immediate postoperative analgesia while serving as a comparator for a prolonged (7-day) high-concentration local anesthetic infusion. The primary goal of the study is to determine if extended neural blockade can disrupt the development of chronic phantom limb pain by preventing the establishment of reentrant neural pathways.

Other names

Control continuous peripheral nerve blocks