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"Control eye drops" is a generic designation used to identify the comparator intervention in clinical trials, specifically those conducted by CooperVision (e.g., NCT02441205) to evaluate treatments for contact lens discomfort. In these randomized, controlled studies, the control eye drop serves as a reference point to measure the efficacy and safety of a new "test" rewetting solution. These drops are typically standard, commercially available ocular lubricants or saline-based solutions designed to improve lens hydration and reduce friction between the contact lens and the ocular surface. Because the term is a protocol-specific placeholder, the exact chemical composition is not fixed and depends on the specific trial design, although it generally functions as a rewetting agent for symptomatic soft contact lens wearers.
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