contulakin-g

Contulakin-G is a synthetic peptide modeled after a natural compound found in the venom of the marine snail Conus geographus. It is a broad-spectrum, non-opioid analgesic that acts as an agonist at neurotensin receptors (NTS1, NTS2, and NTS3), with particular activity at neurotensin receptor 2 (NTS2). Its mechanism involves activation of these receptors to inhibit R-type voltage-gated calcium channels in sensory neurons, leading to potent antinociceptive effects without significant motor block or tolerance. Contulakin-G has demonstrated strong analgesic activity in animal models of acute and inflammatory pain following intrathecal administration. The drug was developed for chronic intractable pain, especially for patients with spinal cord injury, and reached clinical development with orphan drug designation by the FDA[1][2][4][5][6].

Other names

Contulakin-G