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convalescent plasma (Azienda Ospedaliero-Universitaria Pisana)
- Development stage
- Unknown
- Lead developer
- Istituto Superiore di Sanità
- Administration
- Intravenous
01
Overview
Convalescent plasma is a biologic therapy consisting of hyperimmune plasma collected from donors who have recovered from COVID-19. This plasma contains high titers of neutralizing antibodies specifically directed against the SARS-CoV-2 virus. In the TSUNAMI (TranSfUsion of coNvaleScent plAsma for the treatment of severe pneuMonIa due to SARS-CoV2) study, a Phase 2 trial led by Azienda Ospedaliero Universitaria Pisana, the therapy was investigated as a passive immunotherapy for hospitalized patients with COVID-19 pneumonia. The mechanism of action involves the transfusion of these antibodies to neutralize viral particles, inhibit viral entry into host cells, and potentially modulate the inflammatory response in critically ill patients.
- Other names
- hyperimmune plasmaCOVID-19 convalescent plasmaCOVID19 convalescent plasmaCOVID 19 convalescent plasma
02
Targets
SARS-CoV-2 spike
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