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convalescent plasma (Columbia University)

Development stage
Unknown
Lead developer
Andrew Eisenberger
Modality
Antibody-Based Therapeutics
Administration
Intravenous
01

Overview

Convalescent plasma is a passive immunotherapy derived from the blood of individuals who have recovered from COVID-19. It contains a diverse pool of polyclonal antibodies, including neutralizing antibodies that specifically target the SARS-CoV-2 virus. The therapy works by transferring these pre-formed antibodies to patients with early-stage or mild disease to neutralize viral particles, inhibit viral entry into host cells, and reduce the overall viral load, thereby preventing the progression to severe illness. This specific clinical program, led by Andrew Eisenberger at Columbia University, evaluates the efficacy and safety of high-titer convalescent plasma compared to a control (5% albumin) in outpatients with early mild or asymptomatic COVID-19 who are at high risk for disease progression.

Other names
anti-SARS-CoV-2 plasmaanti-SARS-CoV2 plasmaanti-SARS-CoV 2 plasmaCOVID-19 convalescent plasmaCOVID19 convalescent plasmaCOVID 19 convalescent plasmaCPhuman anti-SARS-CoV-2 plasma
02

Targets

RBD (SARS-CoV-2 spike receptor-binding domain)BVDV E2 (Bovine viral diarrhea virus glycoprotein E2)

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