Drug intelligence / Profile preview

convalescent plasma (Fundación Cardiovascular de Colombia)

Development stage
Unknown
Lead developer
Fundación Cardiovascular de Colombia
Administration
Intravenous
01

Overview

Convalescent plasma is a biological therapy derived from the blood of individuals who have recovered from a specific infection—in this context, SARS-CoV-2. It contains high titers of neutralizing antibodies that can provide passive immunity to patients with active disease. The Fundación Cardiovascular de Colombia (Hospital Internacional de Colombia) initiated a quasi-experimental study to evaluate the clinical response of critically ill adult COVID-19 patients in the Intensive Care Unit (ICU) who received 500 ml of ABO-compatible convalescent plasma obtained via apheresis. The primary objective of this institutional program was to establish the impact on 30-day in-hospital mortality and the requirement for mechanical ventilation, particularly in patients experiencing severe systemic inflammatory responses or cytokine storms associated with COVID-19.

Other names
convalescent plasma-Fundación Cardiovascular de Colombia-COVID-19COVID-19 convalescent plasmaCOVID19 convalescent plasmaCOVID 19 convalescent plasmaCCP
02

Targets

SARS-CoV-2 spike

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