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convalescent plasma-Erasmus Medical Center-COVID-19
- Development stage
- Discontinued
- Lead developer
- Erasmus MC
- Administration
- Intravenous
01
Overview
Convalescent plasma-Erasmus Medical Center-COVID-19 refers to a passive immunotherapy developed and studied by Erasmus Medical Center for the treatment of COVID-19. The therapy consists of plasma containing high titers (at least 1:80) of anti-SARS-CoV-2 neutralizing antibodies collected from donors who have recovered from the virus. By providing these pre-formed antibodies to hospitalized or early-stage patients, the treatment aims to neutralize viral particles, reduce viral load, and prevent the progression of the disease. This specific institutional program was evaluated in the ConCOVID randomized trial (NCT04342182), which compared the infusion of 300mL of convalescent plasma against standard of care in symptomatic COVID-19 patients.
- Other names
- convalescent plasmaconvPErasmus MC convalescent plasma
02
Targets
SARS-CoV-2 spike non-RBD epitopesRBD (SARS-CoV-2 spike receptor-binding domain)
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