Drug intelligence / Profile preview

convalescent plasma-Erasmus Medical Center-COVID-19

Development stage
Discontinued
Lead developer
Erasmus MC
Administration
Intravenous
01

Overview

Convalescent plasma-Erasmus Medical Center-COVID-19 refers to a passive immunotherapy developed and studied by Erasmus Medical Center for the treatment of COVID-19. The therapy consists of plasma containing high titers (at least 1:80) of anti-SARS-CoV-2 neutralizing antibodies collected from donors who have recovered from the virus. By providing these pre-formed antibodies to hospitalized or early-stage patients, the treatment aims to neutralize viral particles, reduce viral load, and prevent the progression of the disease. This specific institutional program was evaluated in the ConCOVID randomized trial (NCT04342182), which compared the infusion of 300mL of convalescent plasma against standard of care in symptomatic COVID-19 patients.

Other names
convalescent plasmaconvPErasmus MC convalescent plasma
02

Targets

SARS-CoV-2 spike non-RBD epitopesRBD (SARS-CoV-2 spike receptor-binding domain)

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