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Convalescent plasma-Fundacion Infant-COVID-19 refers to a specific high-titer passive immunotherapy protocol developed by Fundacion INFANT in Argentina. The therapy utilizes plasma collected from recovered COVID-19 patients containing high levels of IgG antibodies (titers >1:1000) specifically targeting the SARS-CoV-2 spike protein. It is intended for early administration, ideally within 72 hours of symptom onset, to elderly patients or those with comorbidities presenting with mild COVID-19. By providing a concentrated dose of neutralizing antibodies, the treatment aims to neutralize the virus and prevent progression to severe respiratory disease. Clinical trial results published in the New England Journal of Medicine demonstrated a significant reduction in the risk of severe respiratory illness in the elderly population when administered early.
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