Conventional neuromuscular blockade-Seoul National University Hospital

Conventional neuromuscular blockade-Seoul National University Hospital refers to a specific treatment arm in a clinical trial (NCT02249585) evaluating anesthetic techniques during laparoscopic colon surgery. This protocol involves the administration of rocuronium, a non-depolarizing neuromuscular blocking agent, to maintain a moderate level of muscle relaxation, defined by a train-of-four (TOF) count of 1-2. Rocuronium acts as a competitive antagonist at nicotinic acetylcholine receptors at the neuromuscular junction, effectively blocking the action of acetylcholine and preventing muscle contraction. The trial, conducted by Seoul National University Hospital, compared this conventional approach against deep neuromuscular blockade to assess its impact on surgical conditions and cardiopulmonary function in patients in the Trendelenburg position.

Other names

moderate neuromuscular blockadeconventional neuromuscular blockade