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conventional therapy-Zhujiang Hospital-primary nephrotic syndrome-chronic kidney disease

Development stage
Unknown
Lead developer
Southern Medical University Zhujiang Hospital
Modality
Small Molecules
Administration
Oral, Subcutaneous, Intravenous
01

Overview

This conventional therapy refers to the standard-of-care treatment protocol utilized at Zhujiang Hospital for patients with primary nephrotic syndrome (PNS) and stage 3-4 chronic kidney disease (CKD). It is a multi-drug regimen designed to manage hypertension and provide renal protection. The protocol includes antihypertensive agents such as amlodipine (a calcium channel blocker), valsartan (an angiotensin II receptor blocker), metoprolol (a beta-blocker), and terazosin (an alpha-1 blocker). Additionally, it incorporates renal protective measures such as Bailing capsules (a traditional Chinese medicine derived from Cordyceps sinensis), alpha-keto acids (to manage nitrogen balance and reduce uremic toxins), and low molecular weight heparin (for its anticoagulant and potential anti-inflammatory properties). This regimen serves as the control arm in clinical studies evaluating novel therapies like Rituximab and mesenchymal stem cells in this patient population.

Other names
conventional therapy
02

Targets

AGTR1 (Angiotensin II Type-1 receptor)LTCC (Voltage-gated calcium channel (L-type))

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