Cook-Waite Lidocaine HCl and Epinephrine

Cook-Waite Lidocaine with Epinephrine is an FDA-approved local anesthetic combination product marketed by Septodont under the Cook-Waite brand for dental pain management. The formulation contains lidocaine hydrochloride 2% as the active anesthetic agent combined with epinephrine (available in concentrations of 1:50,000 or 1:100,000) as a vasoconstrictor. Lidocaine works by blocking voltage-gated sodium channels to inhibit nerve conduction, while epinephrine acts on adrenergic receptors to produce local vasoconstriction, which prolongs the anesthetic effect and improves hemostasis. This small molecule combination is administered via injectable cartridges for local infiltration or nerve block techniques in routine dental procedures. The product provides rapid onset of anesthesia with a duration of approximately 60 to 90 minutes depending on the technique used.

Brand names

Cook-Waite Lidocaine HCl 2% and Epinephrine 1:100,000Cook-Waite Lidocaine HCl 2% and Epinephrine 1:50,000

Other names

Lidocaine 2% with epinephrine 1:50,000Lidocaine 2% with epinephrine 1:100,000Cook-Waite Lidocaine