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Cooperstown Cocktail
- Development stage
- Unknown
- Modality
- Small Molecules
- Administration
- Oral, Intravenous
01
Overview
The Cooperstown Cocktail is a standardized combination of five pharmaceutical drugs: midazolam, omeprazole, warfarin, caffeine, and dextromethorphan. It is primarily used as a phenotyping cocktail in clinical studies to simultaneously assess the activity of multiple drug-metabolizing enzymes, particularly various cytochrome P450 (CYP) isoforms, N-acetyltransferase-2 (NAT2), and xanthine oxidase (XO). Each component serves as a probe substrate for a specific enzyme, allowing researchers to evaluate drug-drug interactions and individual variability in drug metabolism. This cocktail is a valuable tool in pharmacokinetic research to understand how new drugs might affect or be affected by these metabolic pathways.
- Other names
- Cooperstown 5+1 cocktailmodified Cooperstown cocktailMCC
02
Targets
CYP2C19 (Cytochrome P450 2C19)CYP1A2 (Cytochrome P450 1A2)XO (Xanthine Oxidoreductase)CYP2C9 (Cytochrome P450 family 2 subfamily C member 9)CYP3A7 (Cytochrome P450 3A7)NAT (Arylamine N-acetyltransferase 2)
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