Drug intelligence / Profile preview

copper (64Cu) edotreotide

Development stage
Unknown
Lead developer
Voxel Tech
Modality
Antibody-Radionuclide Conjugates → Antibody Conjugates → Antibody-Based Therapeutics, Peptides
Administration
Intravenous
01

Overview

V-Cu64 is a radiopharmaceutical diagnostic imaging agent developed by Voxel S.A., consisting of the somatostatin analog edotreotide (DOTATOC) labeled with the positron-emitting radioisotope copper-64 (Cu-64). It is designed for PET-CT imaging of neuroendocrine tumors (NETs) that overexpress somatostatin receptors, particularly SSTR2. The use of Cu-64 provides a longer half-life (12.7 hours) compared to the more common Gallium-68 (68 minutes), facilitating centralized production and distribution. In clinical evaluation, V-Cu64 is being compared to Ga-68 DOTATOC to demonstrate bioequivalence in lesion detection and standardized uptake values (SUVmax) in patients with suspected or confirmed NETs.

Other names
Cu-64 DOTATOCCu64 DOTATOCCu 64 DOTATOC[64Cu]Cu-DOTATOC64Cu-edotreotide64Cu-DOTATOC
02

Targets

SSTR1 (Somatostatin Receptor Type 1)SSTR2 (Somatostatin receptor type 2)SSTR3 (Somatostatin receptor 3)SSTR4 (Somatostatin receptor 4)SSTR5 (Somatostatin receptor 5)

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