Clinical trials
Full profile accessFollow clinical development from study design and recruitment through results.
- Trial phase
- Status
- Readouts
Drug intelligence / Profile preview
copper + dimercaptosuccinic acid + polyethylene glycol
- Development stage
- Preclinical
- Lead developer
- Harbin Medical University
- Modality
- Nanoparticles → Drug Delivery Systems
- Administration
- Intravenous
01
Overview
copper + dimercaptosuccinic acid + polyethylene glycol (Cu-DMSA-PEG) is a nanocatalytic therapeutic agent developed for the treatment of non-small cell lung cancer (NSCLC). It consists of a copper-based catalytic core stabilized by dimercaptosuccinic acid (DMSA) and surface-modified with polyethylene glycol (PEG) to enhance biocompatibility and prolong systemic circulation. The nanoparticle operates through a chemodynamic therapy (CDT) mechanism; upon internalization into the tumor microenvironment, the copper ions deplete intracellular glutathione (GSH) and catalyze a Fenton-like reaction to generate reactive oxygen species (ROS). This sustained oxidative stress induces ferroptosis, downregulates the expression of glutathione peroxidase 4 (GPX4), and inhibits DNA replication, ultimately suppressing tumor progression. While related formulations may include targeting moieties like hyaluronic acid, the PEGylated version serves as a stable, long-circulating nanocatalyst for tumor-specific oxidative damage.
- Other names
- Cu-DMSA-PEG nanoparticlesPEGylated copper-dimercaptosuccinic acid nanoparticles
02
Targets
GSH (Glutathione)GPX4 (Glutathione peroxidase 4)DNA
Beyond the preview
Go deeper on copper + dimercaptosuccinic acid + polyethylene glycol.
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Indications & development
Full profile accessExplore development by indication, patient population, and geography.
- Indications
- Development status
- Countries
Licensing & deals
Full profile accessTrace asset ownership, licensing agreements, and commercial partnerships.
- Partners
- Deal terms
- Milestones
Patents & exclusivity
Full profile accessExplore the patent landscape and regulatory exclusivity around an asset.
- Patents
- Expiration dates
- Exclusivity
Competitive landscape
Full profile accessCompare development programs by target, modality, and indication.
- Competing assets
- Targets
- Development stage
Research & analysis
Full profile accessConnect source evidence and development news to your research questions.
- Publications
- News
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on copper + dimercaptosuccinic acid + polyethylene glycol.