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copper cu 64-dota b-fab

Development stage: Phase 1
Lead developer: Stanford University
Modality: Antibody-Radionuclide Conjugates → Antibody Conjugates → Antibody-Based Therapeutics, Recombinant Proteins and Enzymes, Antibody Fragments → Engineered Antibody Formats → Antibody-Based Therapeutics
Administration: Intravenous

Overview

Copper Cu 64-DOTA B-Fab is a radiopharmaceutical agent composed of a humanized antibody fragment (B-Fab) conjugated to the chelator DOTA and labeled with the positron-emitting radioisotope copper-64. It is designed for use as a PET imaging tracer to evaluate expression of cancer antigen CA6 in tumors, particularly in patients with ovarian and breast cancer. The mechanism involves specific binding of the B-Fab fragment to CA6-expressing tumor cells, allowing for non-invasive visualization and localization using PET/CT imaging. This agent enables assessment of CA6 status in tumors, which may inform diagnosis or therapeutic planning[3].

Other names: 64Cu-DOTA-B-Fabcopper-64 DOTA B-Fabcopper64 DOTA B-Fabcopper 64 DOTA B-Fab

Targets

CA6 (Carbonic Anhydrase 6)

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