copper diethyldithiocarbamate

Copper diethyldithiocarbamate is a small molecule copper complex formed by chelation of copper(II) ions with diethyldithiocarbamate ligands. It is the active anticancer agent generated from disulfiram in the presence of copper, showing cytotoxic activity against tumor cells via inhibition of the proteasome, specifically targeting the 19S lid of the proteasome. Therapeutically, it is primarily being investigated for anticancer uses, including glioma and leukemia models, where liposomal formulations have increased efficacy and bioavailability in animal studies. Its pharmacological activity is distinct from its precursor disulfiram, and the compound is poorly water-soluble, presenting formulation challenges for therapeutic use[1].

Other names

copper(II) diethyldithiocarbamatediethyldithiocarbamic acid copper saltcupric diethyldithiocarbamatecopper diethyl dithiocarbamatebis(N,N-diethyldithiocarbamate)copper(II) complexCu-DDC complexcopper(2+) diethyldithiocarbamateaccelerator CDC4567-99-1Cu(DDC)2