coptisine

Coptisine is a natural protoberberine alkaloid primarily extracted from the medicinal plant *Coptis chinensis* (Rhizoma Coptidis) and *Chelidonium majus*. It is chemically related to berberine and has been extensively studied for its diverse pharmacological activities, including anti-inflammatory, antimicrobial, and antineoplastic properties. Research indicates that coptisine exerts anti-tumor effects by modulating several key intracellular signaling pathways; notably, it has been shown to block the progression of bladder cancer by inhibiting the **PI3K/AKT pathway**, which reduces cell proliferation and induces apoptosis. Beyond oncology, coptisine is investigated for its potential in treating metabolic disorders such as diabetes and hyperlipidemia, often through the activation of **AMP-activated protein kinase (AMPK)**. It also shows inhibitory activity against monoamine oxidase and topoisomerases.

Other names

coptisine chloridebis(methylenedioxy)protoberberine6,7-dihydro-bis[1,3]benzodioxolo[5,6-a:4',5'-g]quinolizinium