corallopyronin A

Corallopyronin A is a natural product antibiotic isolated from Corallococcus coralloides that inhibits the bacterial DNA-dependent RNA polymerase at a distinct target site, showing activity against Gram-positive bacteria and intracellular Gram-negative pathogens including Wolbachia, Chlamydia spp., Rickettsia spp., and Orientia tsutsugamushi.[9][1] It depletes Wolbachia endosymbionts essential for filarial nematode survival, resulting in macrofilaricidal effects and positioning it as a candidate for treating onchocerciasis and lymphatic filariasis; preclinical work includes solid oral formulations to improve stability and bioavailability and robust in vivo efficacy in filarial models.[9][3][7] Development is led within the German Center for Infection Research network with contributions from Helmholtz Centre for Infection Research and academic partners; GMP production and scale-up have been established with contract manufacturers to support first-in-human trials.[3]

Other names

corallopyroninmethyl N-[(E)-5-[4-hydroxy-5-[(2E,4E,9E,12E)-8-hydroxy-2,5,9-trimethyltetradeca-2,4,9,12-tetraenoyl]-6-oxopyran-2-yl]hex-1-enyl]carbamate[8]methyl N-((E)-5-(4-hydroxy-5-((2E,4E,9Z,12E)-8-hydroxy-2,5,9-trimethyltetradeca-2,4,9,12-tetraenoyl)-6-oxopyran-2-yl)hex-1-enyl)carbamate[2]CAS 96789-48-9[8]