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cord blood-derived gamma delta T cells + cord blood-derived natural killer cells
- Development stage
- Preclinical
- Lead developer
- CytoMed Therapeutics China
- Modality
- CAR-NK Cells → Other Engineered Cells → Adoptive Cell Transfer → Cell Therapies, Lymphokine-Activated Killer Cells → Native Immune Cells → Adoptive Cell Transfer → Cell Therapies
- Administration
- Intravenous
01
Overview
This combination cell therapy, developed by LongevityBank, utilizes gamma delta (γδ) T cells and natural killer (NK) cells derived from umbilical cord blood for the treatment of various cancer types. These specific immune cell populations are characterized by their innate ability to recognize and eliminate tumor cells in a non-MHC-restricted manner, which potentially allows for 'off-the-shelf' therapeutic applications with a reduced risk of graft-versus-host disease (GvHD) compared to conventional αβ T-cell therapies. The therapy leverages the robust cytotoxic activity of both γδ T cells and NK cells to target multiple tumor types through cell-mediated cytotoxicity.
- Other names
- gamma delta T cellsgamma-delta T cellsNK cellscord blood-derived gamma delta T cellscord blood-derived NK cellscord blood-derived γδ T cells
02
Targets
NCR3LG1 (Natural cytotoxicity triggering receptor 3 ligand 1)BTN2A1 (Butyrophilin subfamily 2 member A1)MICB (Major histocompatibility complex class i-related protein B)
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