cord blood-derived mesenchymal stem cells

Cord blood-derived mesenchymal stem cells are multipotent stem cells isolated from human umbilical cord blood that can differentiate into several cell types including osteogenic, chondrogenic, adipogenic, and myogenic lineages. They display strong immunomodulatory effects through secretion of cytokines, chemokines, and extracellular vesicles, and can migrate to sites of inflammation and injury. Their therapeutic potential includes use in regenerative medicine, tissue engineering, autoimmune and inflammatory diseases, graft-versus-host disease (GvHD), and as adjuncts to hematopoietic stem cell transplantation. Compared to adult MSCs, cord blood-derived MSCs are easier to harvest, have higher stemness and proliferative capacity, and show enhanced immune tolerance, allowing broader allogeneic use[1][5][6][4]. Mechanistically, they exert their action via paracrine signaling that modulates immune cell function, inhibits apoptosis, fosters angiogenesis, reduces inflammation, and aids tissue repair[2][4][8]. Clinical studies have explored their use for diabetes, bone and joint disorders, neurological, cardiovascular, auto-immune, liver diseases, and as supportive therapy for hematopoietic engraftment[5][4][1].

Other names

cord blood MSCscord MSCsumbilical cord blood-derived mesenchymal stem cellsCB-MSCs