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cord blood hematopoietic stem cells
- Development stage
- Phase 2
- Lead developer
- University of Brescia
- Modality
- Stem Cell Therapies → Cell Therapies
- Administration
- Intrabone
01
Overview
Cord blood hematopoietic stem cells (HSCs) are multipotent stem cells derived from umbilical cord blood, used as an alternative source for allogeneic hematopoietic stem cell transplantation (HSCT). In the specific clinical context evaluated by the Università degli Studi di Brescia, these cells are administered via intra-bone (intramedullary) injection rather than the standard intravenous route. This approach is designed to enhance the homing of HSCs directly to the bone marrow niche, potentially overcoming the common limitation of low total nucleated cell counts in single cord blood units, which often hinders successful engraftment in adult patients. The procedure is primarily investigated for patients with various hematologic neoplasms who lack a suitable HLA-matched bone marrow or peripheral blood donor.
- Other names
- Intra-bone cord blood hematopoietic stem cell transplantationIntra-bone cord blood transplantationIntra-bone HSC infusion of CB
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