cordycepin triphosphate

Cordycepin triphosphate is the triphosphorylated form of cordycepin (3’-deoxyadenosine), a purine nucleoside analog derived from the fungus Cordyceps militaris. It is a purine ribonucleoside 5′-triphosphate and acts as an antimetabolite with antifungal, antineoplastic, antiviral, and immunomodulatory properties[2][9]. Mechanistically, cordycepin triphosphate mimics adenosine triphosphate (ATP) due to its structural similarity and can be incorporated into RNA by cellular enzymes in place of ATP. This incorporation disrupts normal RNA synthesis by inhibiting polyadenylation and acting as an RNA elongation inhibitor[2][5]. It also inhibits mTOR signaling via activation of AMP-activated protein kinase (AMPK), leading to reduced cell proliferation and induction of apoptosis in tumor cells[2][5]. The compound has been used experimentally as a transcriptional inhibitor in molecular biology assays[3], but it is not approved for clinical use.

Other names

3'-deoxyadenosine 5'-triphosphate3'-dATP3'-deoxy-ATPCordycepin 5'-triphosphate