Drug intelligence / Profile preview

cordyceps

Development stage
Phase 3
Modality
Microbiome-Derived Products → Microbiome Therapeutics, Small Molecules
Administration
Oral
01

Overview

Cordyceps is a genus of parasitic fungi traditionally used in Chinese medicine. The most well-known species for medicinal use are Cordyceps sinensis and Cordyceps militaris. Cordyceps supplements are available as capsules or extracts and are promoted for a variety of health benefits including boosting energy and stamina; supporting immune function; improving kidney health; reducing inflammation; stabilizing blood sugar levels; lowering cholesterol; enhancing sexual performance; and potentially inhibiting tumor growth[2][3][4][5][6]. Mechanistically in laboratory studies and animal models it has been shown to stimulate T helper cells and natural killer cell activity; prolong lymphocyte survival; enhance production of TNF-alpha and IL1 cytokines; inhibit platelet aggregation via cordycepin content by lowering calcium ion/thromboxane A2 activity[5]; downregulate MHC class II antigen expression on tumor cells[5]; reduce oxidative stress through antioxidant effects[2][4]; lower blood glucose/lipids in diabetes models[2][6]; improve renal function markers in chronic kidney disease patients[4]. However most clinical evidence is limited or inconclusive with few large-scale human trials.

Other names
Cordyceps sinensisOphiocordyceps sinensisAwetoCaterpillar FungusCaterpillar MushroomsChampignon ChenilleChinese Caterpillar FungusCs-4Cs4Cs 4Dong Chong Xia CaoDong Chong Zia CaoKeeda GhasKeera JharOrphiocordyceps Sinensis (variant spelling)SemitakeTochukasoVegetable CaterpillarWinter Worm Summer Grass (Winter Worm Summer Grass)XinGanBaoYarshagumba (Yarsha gumba)Yartsa Gunbu (Yatsa Gunbu)Zhiling
02

Targets

ACE (Angiotensin Converting Enzyme)

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