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cordyceps chinensis
- Development stage
- Preclinical
- Lead developer
- NuCana
- Modality
- Metabolically Activated Prodrugs → Prodrugs/Conditional Activator Small Molecules → Small Molecules, Classical Binding Small Molecules → Small Molecules
- Administration
- Oral
01
Overview
*Cordyceps chinensis* (scientifically known as *Ophiocordyceps sinensis*) is a parasitic fungus that grows on the larvae of ghost moths and is highly valued in traditional Chinese medicine (TCM). It contains several bioactive compounds, most notably cordycepin (3'-deoxyadenosine) and various polysaccharides, which contribute to its immunomodulatory, anti-inflammatory, and anti-tumor properties. In oncological research, *Cordyceps chinensis* has been shown to inhibit the viability of cancer cells, including pancreatic adenocarcinoma lines such as BxPC-3 and Panc-1, primarily by inducing apoptosis and suppressing cell proliferation. It is often utilized as a dietary supplement or as an adjuvant therapy in combination with traditional chemotherapeutic agents.
- Other names
- Ophiocordyceps sinensiscaterpillar fungusDong Chong Xia Cao
02
Targets
PARP1 (Poly (adp-ribose) polymerase 1)
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