Drug intelligence / Profile preview

cordyceps sinensis

Development stage
Phase 4
Modality
Bacterial Strains → Single Strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Yeast Strains → Single Strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Defined Consortia → Multi-strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Complex Communities → Multi-strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Fresh FMT → Fecal Microbiota Transplantation (FMT) → Microbiome Therapeutics, Frozen FMT → Fecal Microbiota Transplantation (FMT) → Microbiome Therapeutics, Genetically Modified Bacteria → Engineered Microbial Therapeutics → Microbiome Therapeutics, Synthetic Biology Platforms → Engineered Microbial Therapeutics → Microbiome Therapeutics, Microbial Metabolites → Microbiome-Derived Products → Microbiome Therapeutics, Microbial Proteins → Microbiome-Derived Products → Microbiome Therapeutics, Small Molecules
Administration
Oral
01

Overview

Cordyceps sinensis is a parasitic medicinal fungus traditionally used in Chinese medicine for centuries. It grows on the larvae of certain moths and is highly valued for its purported health benefits. The main bioactive compounds include cordycepin (3-deoxyadenosine), polysaccharides, and d-mannitol. Cordyceps sinensis has been studied for its anti-inflammatory, antioxidant, immunomodulatory, antitumor, anti-aging, and adaptogenic properties[2][5][6]. Mechanistically, it appears to modulate immune responses by enhancing natural killer cell activity and propagating helper T cells; it also exhibits effects on energy metabolism (possibly increasing ATP production), supports kidney function (notably in chronic kidney disease), improves respiratory function by enhancing oxygen utilization during exercise or illness[5][7], may lower blood sugar levels via insulin modulation[6], and shows potential cardiovascular benefits such as lowering LDL cholesterol and triglycerides[6]. While animal studies are promising regarding inflammation reduction (e.g., arthritis models) and improved aerobic performance or fatigue resistance in humans[2][4], robust clinical evidence remains limited. Cordyceps sinensis is difficult to harvest naturally; most supplements use cultivated strains like CS-4 due to cost constraints[2].

Other names
dong chong xia caochinese caterpillar funguswinter-worm summer-grass蛹虫草菌粉
02

Targets

ADK (Adenosine kinase)CASP3 (Caspase-3)CPT2 (Carnitine O-palmitoyltransferase 2)CD4 (T lymphocyte surface antigen)EGFR (Epidermal growth factor receptor)IL-6 (Interleukin 6)RNAP (Bacterial dna-dependent RNA polymerase)

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