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**CORE** is a proprietary oral, multi-ingredient dietary-supplement formulation developed by Soy Labs for weight management and metabolic-risk reduction. It contains a standardized *Cissus quadrangularis* extract identified as CQR-300 together with niacin-bound chromium, green tea extract, selenium, soy albumin, vitamin B6, vitamin B12, and folic acid. In controlled studies in overweight and obese adults, CORE was administered as capsules twice daily for eight weeks and was associated with reductions in body weight, body fat, fasting glucose, total cholesterol, LDL cholesterol, triglycerides, and oxidative-stress biomarkers; the evidence derives from small published trials rather than regulatory approval studies. ([pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/17274828/))
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