corifollitropin alfa + clomiphene citrate

A combination fertility treatment regimen that pairs corifollitropin alfa, a long-acting follicle stimulant, with clomiphene citrate, an oral selective estrogen receptor modulator. Corifollitropin alfa is a sustained follicle stimulant with similar pharmacological effects to recombinant follicle stimulating hormone (rFSH) but with a longer elimination half-life, allowing a single injection to replace 7 daily injections of traditional FSH. Clomiphene citrate is an orally administered ovulatory stimulant that competes with estrogen for estrogen-receptor-binding sites, which increases the release of pituitary gonadotropins. This combination is used in controlled ovarian stimulation protocols for women undergoing assisted reproductive technologies.