corilagin

Corilagin is a natural polyphenolic compound classified as an ellagitannin (a type of hydrolyzable tannin) and a gallate ester, commonly found in several plants including Caesalpinia coriaria, Phyllanthus tenellus, Phyllanthus urinaria, and Punica granatum (pomegranate)[1][4][5][7][10]. It exhibits diverse biological activities such as antihypertensive, non-steroidal anti-inflammatory, antioxidant, anti-tumor, hepatoprotective, anti-fibrotic, and potentially antiepileptic effects[1][3][4][6][7][8][9][10]. Mechanistically, corilagin is reported as an inhibitor of peptidyl-dipeptidase A (angiotensin-converting enzyme, ACE), carbonic anhydrase, squalene epoxidase (inhibiting cholesterol synthesis), and an inhibitor of NLRP3 inflammasome-mediated inflammatory pathways[1][7][8][9][10]. Experimental studies also suggest it can block ERK/JNK MAPK and NF-κB pro-inflammatory signaling, downregulate glucose regulated protein 78 (GRP78), and reduce pro-inflammatory cytokines and oxidative stress markers[3][4][6][9][10]. While it has shown therapeutic potential in preclinical models for hypertension, inflammation, cancer, hepatoprotection, fibrosis, and epilepsy, corilagin has not yet been developed or approved as a pharmaceutical drug in humans[9][10].

Other names

23094-69-1CHEBI:3884[(1S,19R,21S,22R,23R)-6,7,8,11,12,13,22,23-octahydroxy-3,16-dioxo-2,17,20-trioxatetracyclo[17.3.1.04,9.010,15]tricosa-4,6,8,10,12,14-hexaen-21-yl] 3,4,5-trihydroxybenzoate