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Corina Intrauterine Drug-Eluting System

Development stage: Unknown
Lead developer: Yipurun
Modality: Small Molecules
Administration: Intrauterine

Overview

Corina is an innovative drug-device-combination therapy developed by Yipurun (Shanghai) Biotechnology Co., Ltd., a wholly-owned subsidiary of Puyi (Shanghai) Biotechnology Co., Ltd. It is made from non-degradable, medical-grade material and contains the active ingredient estradiol. Designed to conform to the shape of the female uterus, Corina acts as a physical barrier upon insertion and enables targeted delivery of estradiol to the endometrium. It continuously releases estradiol for up to 60 days post-procedure to promote endometrial growth and prevent re-adhesion. Corina has been approved in China for treating moderate-to-severe intrauterine adhesions (IUA) in patients undergoing transcervical resection of adhesions (TCRA).

Brand names: Corina
Other names: 17-beta estradiol-eluting intrauterine stentCorina Intrauterine Drug-Eluting System

Targets

ESR2 (ERβ)ESR1 (ERα)

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