corticosteroid + pentoxifylline

This is a combination therapy consisting of a corticosteroid (such as prednisolone) and pentoxifylline, used primarily in the treatment of severe alcoholic hepatitis. Corticosteroids are anti-inflammatory agents that suppress immune responses and reduce liver inflammation, while pentoxifylline is a phosphodiesterase inhibitor with anti-TNF effects that may help reduce complications such as hepatorenal syndrome. The combination has been studied to determine if it offers additional benefits over monotherapy; evidence suggests it does not significantly improve overall survival compared to corticosteroids alone but may reduce the incidence of hepatorenal syndrome or acute kidney injury and infection risk[1][2][3][5]. The primary indication for this combination is severe alcoholic hepatitis.