cortistatin

Cortistatin is an endogenous cyclic neuropeptide that shares high structural homology with somatostatin but possesses distinct biological functions. It acts as a potent agonist for all five somatostatin receptors (SSTR1-5) and also interacts with the ghrelin receptor (GHSR1a) and the Mas-related gene X2 (MrgX2). Cortistatin is involved in regulating sleep, neuronal activity, and immune responses. In the context of oncology, particularly prostate cancer, it has been shown to inhibit cell proliferation and migration in androgen-independent models by modulating AKT and JNK signaling pathways. It also exhibits potent anti-inflammatory and immunomodulatory properties, making it a candidate for treating autoimmune and inflammatory conditions like sepsis and rheumatoid arthritis.

Other names

Cortistatin-14Cortistatin14Cortistatin 14Cortistatin-17Cortistatin17Cortistatin 17Cortistatin-29Cortistatin29Cortistatin 29