Drug intelligence / Profile preview

corydalis decumbens

Development stage
Preclinical
Lead developer
Jiangxi Tianshikang Traditional Chinese Medicine
Administration
Oral
01

Overview

Corydalis decumbens (Chinese name 夏天无, Xia Tian Wu) is a traditional Chinese medicinal herb known as Rhizoma Corydalis Decumbentis or Decumbent Corydalis Tuber. It is used in Traditional Chinese Medicine (TCM) primarily to decrease blood pressure, relieve spasm, promote the circulation of qi, alleviate pain, activate blood and dissipate blood stasis. Indications include hypertension, sciatica, polio syndrome sequelae (such as hemiplegia), rheumatic arthritis and limb numbness. The herb is typically administered as a decoction or powder and can also be formulated into tablets or pills[1][5]. Compound formulations such as Fufang Xiatianwu Pian are used for conditions like rheumatoid arthritis and sciatica[2][4]. The mechanism of action is not fully elucidated but involves vasodilation and anti-inflammatory effects according to pharmacological studies[2].

Brand names
Fufang Xiatianwu Pian
Other names
Xia Tian Wu夏天无Rhizoma Corydalis DecumbentisDecumbent Corydalis Tuber
02

Targets

CYP2C19 (Cytochrome P450 2C19)FOS (Activator Protein 1)TLR4 (Toll-like receptor 4)CYP1A2 (Cytochrome P450 1A2)NF-κBCYP3A4 (Cytochrome P450 3A4)RK (Ribokinase)JNK (Mitogen-activated protein kinase kinase kinase family)

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