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corynebacterium parvum + fluorouracil + melphalan
- Development stage
- Preclinical
- Modality
- Bacterial Strains → Single Strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Yeast Strains → Single Strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Defined Consortia → Multi-strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Complex Communities → Multi-strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Fresh FMT → Fecal Microbiota Transplantation (FMT) → Microbiome Therapeutics, Frozen FMT → Fecal Microbiota Transplantation (FMT) → Microbiome Therapeutics, Genetically Modified Bacteria → Engineered Microbial Therapeutics → Microbiome Therapeutics, Synthetic Biology Platforms → Engineered Microbial Therapeutics → Microbiome Therapeutics, Microbial Metabolites → Microbiome-Derived Products → Microbiome Therapeutics, Microbial Proteins → Microbiome-Derived Products → Microbiome Therapeutics, Small Molecules
- Administration
- Intravenous, Oral, Subcutaneous, Intramuscular
01
Overview
This is a combination therapy consisting of three agents: Corynebacterium parvum, fluorouracil, and melphalan. - **Corynebacterium parvum** is a killed bacterial preparation used as an immunotherapeutic agent. It acts as a non-specific immunopotentiator by stimulating the immune system, particularly enhancing macrophage activity and increasing immunoglobulin levels, which may contribute to anti-tumor effects[1][2][3]. - **Fluorouracil (5-FU)** is an antimetabolite chemotherapy drug that inhibits thymidylate synthase, thereby interfering with DNA synthesis and function in rapidly dividing cells (not directly referenced in search results but well-established). - **Melphalan** is an alkylating agent that crosslinks DNA strands, preventing cancer cell replication and leading to cell death[4][5][6]. This combination would be considered investigational or experimental; there are no widely recognized brand names or approvals for this specific triple regimen. Each component has been studied individually or in other combinations for various cancers.
02
Targets
DNAPRR (Pattern recognition receptors)TS (Thymidylate synthase)
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