Drug intelligence / Profile preview

Costus extract

Development stage
Unknown
Lead developer
Tennessee State University
Administration
Oral, Topical
01

Overview

Costus extract refers to botanical preparations derived from plants of the genus *Costus* (such as *Costus speciosus*) or the species *Saussurea costus*. These extracts are widely used in traditional medicine for their anti-inflammatory, anti-microbial, and anti-diabetic properties. In oncological research, methanolic extracts of Costus have been investigated for their ability to inhibit the viability of various cancer cell lines, including lung, colon, breast, and cervical cancers. The therapeutic potential of the extract is largely attributed to bioactive phytochemicals such as sesquiterpene lactones (e.g., costunolide and dehydrocostus lactone), which are known to induce apoptosis and modulate pro-survival signaling pathways. While primarily categorized as a dietary supplement or nutraceutical, it remains a subject of preclinical study for potential therapeutic applications in cancer and metabolic diseases.

Other names
Costus speciosus extractCostus igneus extractSaussurea costus extractMu Xiang
02

Targets

NF-κBSTAT3 (Signal Transducer and Activator of Transcription 3)CASP (Caspase family)

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