COT-01

COT-01: sourced facts only. name: "Here, we report the identification of COT-01, a natural product-derived cortisone analog, as a CRBN-dependent molecular glue degrader of Cyclin D2." [PMID:42849138]; target: "Here, we report the identification of COT-01, a natural product-derived cortisone analog, as a CRBN-dependent molecular glue degrader of Cyclin D2." [PMID:42849138]; developer: "Data Convergence Drug Research Center, Korea Research Institute of Chemical Technology, 141 Gajeong-ro, Yuseong, Daejeon 34114, Republic of Korea." [PMID:42849138]; modality: "Here, we report the identification of COT-01, a natural product-derived cortisone analog, as a CRBN-dependent molecular glue degrader of Cyclin D2." [PMID:42849138]; stage: "Furthermore, in a xenograft mouse model, intraperitoneal administration of COT-01 significantly suppressed tumor growth without significant changes in tumor-free body weight or terminal liver and kidney weights." [PMID:42849138]