Drug intelligence / Profile preview

coumaphos

Development stage
Unknown
Lead developer
Bayer
Modality
Small Molecules
Administration
Topical
01

Overview

Coumaphos is a nonvolatile, fat-soluble organophosphate (phosphorothioate) insecticide and acaricide used primarily in veterinary medicine to control ectoparasites such as ticks, mites, flies, and fleas on farm and domestic animals. It acts as a cholinesterase inhibitor, disrupting nerve function in target pests by inhibiting acetylcholinesterase activity. Coumaphos is applied as dips or washes for livestock and has also been used to control Varroa mites in honey bee colonies; however, its use has declined due to resistance development and concerns about toxicity residues. The compound is classified as an extremely hazardous substance in the United States due to its potential for acute organophosphate poisoning[1][2][3][4].

Brand names
AsuntolAsunthol
Other names
coumafosO,O-Diethyl O-(3-chloro-4-methyl-2-oxo-2H-chromen-7-yl) phosphorothioatePhosphorothioic acid, O-(3-chloro-4-methyl-2H-chromenyl) O,O-diethyl ester
02

Targets

Acetylcholinesterase

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