Drug intelligence / Profile preview

Counterpain COOL

Development stage
Unknown
Lead developer
Taisho Pharmaceutical Indonesia
Modality
Small Molecules
Administration
Topical
01

Overview

Counterpain COOL is a topical gel formulation containing 4% menthol, developed by Taisho Pharmaceutical Indonesia. It is primarily used as a cooling agent to manage thermal sensation and body temperature during physical exertion in hot environments. Menthol acts as a selective activator of the transient receptor potential melastatin 8 (TRPM8) channel, which is responsible for the sensation of cold. By stimulating these cold-sensitive receptors on the skin, the gel provides a cooling effect without a physical drop in temperature, potentially improving thermal comfort and physical performance in athletes or individuals exposed to heat stress.

Brand names
Counterpain COOL
Other names
4% Menthol gelmenthol
02

Targets

TRPM8 (Transient receptor potential cation channel subfamily M member 8)

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