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COVID-19 recombinant protein vaccines are a class of protein subunit vaccines designed to prevent COVID-19 by presenting a laboratory-engineered version of the SARS-CoV-2 spike protein to the immune system. Unlike mRNA or viral vector vaccines, these products deliver the antigen directly, typically in combination with an adjuvant (such as Novavax's Matrix-M or Sanofi's AS03) to enhance immunogenicity. This technology is used in authorized vaccines like Nuvaxovid (Novavax) and VidPrevtyn Beta (Sanofi/GSK). In clinical research, such as studies conducted by the Finnish Institute for Health and Welfare (THL), the term is used to categorize these authorized biologics when evaluating real-world immune responses and vaccine effectiveness against SARS-CoV-2 variants.
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