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**Covifenz** is a plant-based, recombinant virus-like-particle COVID-19 vaccine developed by Medicago with GSK's AS03 adjuvant system. It contains plant-produced virus-like particles displaying SARS-CoV-2 original-strain spike protein and is intended to induce antigen-specific neutralizing and cellular immune responses that help prevent COVID-19. Health Canada authorized the two-dose intramuscular vaccine for adults in February 2022; Medicago cancelled the authorization on March 31, 2023, and the product was discontinued before commercial marketing. ([canada.ca](https://www.canada.ca/en/health-canada/services/drugs-health-products/covid19-industry/drugs-vaccines-treatments/vaccines/medicago.html))
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