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cowhage
- Development stage
- Unknown
- Modality
- Small Molecules
- Administration
- Topical
01
Overview
Cowhage, derived from the tropical legume *Mucuna pruriens*, refers to the plant's spicules or extracts. Its active component, mucunain, is a cysteine protease. Cowhage is widely used in research as an experimental inducer of itch and inflammation, particularly to study non-histaminergic itch pathways in conditions such as atopic dermatitis. It activates protease-activated receptors (PAR-2 and PAR-4) on cutaneous cells and nerve endings.
- Other names
- Mucuna pruriens
02
Targets
MRGPRX1 (Mas-related G protein-coupled receptor X1)MRGPRX2 (Mas-related G-protein Coupled Receptor X2)PAR2 (Protease-activated receptor 2)PAR4 (Protease-activated receptor 4)
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