Drug intelligence / Profile preview

CP-102

Development stage
Preclinical
Lead developer
CardioPharma
Modality
Small Molecules
Administration
Oral
01

Overview

**CP-102** is CardioPharma's investigational fixed-dose cardiovascular polypill comprising **atorvastatin, lisinopril, and aspirin**. The combination is intended to address cardiovascular disease through complementary mechanisms: atorvastatin competitively inhibits HMG-CoA reductase to reduce cholesterol synthesis; lisinopril inhibits angiotensin-converting enzyme to reduce angiotensin II formation and blood pressure; and aspirin irreversibly inhibits platelet cyclooxygenase to suppress thromboxane-mediated platelet aggregation. CardioPharma lists CP-102 as a pipeline line extension based on generic cardiovascular medicines, with no clinical phase or approved marketing status publicly specified. ([cardiopharma.com](https://www.cardiopharma.com/cardiapill-pipeline/))

Other names
atorvastatin + lisinopril + aspirinatorvastatin-lisinopril-ASA
02

Targets

PTGS2 (Prostaglandin-Endoperoxide Synthase 2)ACE (Angiotensin Converting Enzyme)PGHS-1 (Prostaglandin G/H Synthase 1)HMGCR (3-hydroxy-3-methylglutaryl-coenzyme A reductase)

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