cp-94253

CP-94253 is a potent and selective serotonin 5-HT1B receptor agonist, belonging to the tetrahydropyridinylpyrrolopyridine chemical family[1][3]. It exhibits high selectivity for the 5-HT1B receptor over closely related receptors such as 5-HT1D and 5-HT1A[1][3]. In animal studies, CP-94253 has been shown to promote wakefulness by increasing dopamine release, reduce food intake and promote satiety, enhance the reinforcing effects of cocaine, and may have antidepressant-like effects[1][13]. It also attenuates cocaine-seeking behavior and reduces cocaine intake after abstinence, suggesting potential utility in treating substance use disorders[1][10]. CP-94253 is used primarily in preclinical research and is not approved for therapeutic use in humans[3].