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Drug intelligence / Profile preview
CpG 1018-adjuvanted plague vaccine
- Development stage
- Unknown
- Lead developer
- Dynavax Technologies
- Modality
- Vaccines & Immunotherapeutics
- Administration
- Intramuscular
01
Overview
CpG 1018-adjuvanted plague vaccine is a recombinant protein subunit vaccine candidate being developed by Dynavax in collaboration with the U.S. Department of Defense (DoD). The vaccine is designed to provide protection against plague, a severe infectious disease caused by the bacterium *Yersinia pestis*. It combines a recombinant F1-V (rF1V) fusion protein antigen with Dynavax's proprietary CpG 1018 adjuvant. CpG 1018 is a Toll-like receptor 9 (TLR9) agonist that enhances the immune response by mimicking bacterial DNA, thereby stimulating both innate and adaptive immunity. The program is currently in Phase 2 clinical development, aimed at providing a more effective and stable alternative to older plague vaccines for military and public health preparedness.
- Other names
- CpG 1018-adjuvanted plague vaccineCpG1018-adjuvanted plague vaccineCpG-1018-adjuvanted plague vaccineCpG 1018-adjuvanted vaccine for plagueCpG1018-adjuvanted vaccine for plagueCpG-1018-adjuvanted vaccine for plaguerF1V/CpG 1018 plague vaccine
02
Targets
TLR9 (Toll-like receptor 9)F1 antigen (F1 capsular antigen)LcrV (V antigen)
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