CpG oligodeoxynucleotide B344

CpG oligodeoxynucleotide B344 (CpG B344) is a synthetic, single-stranded DNA molecule containing unmethylated cytosine-guanine (CpG) motifs, specifically categorized as a Class B CpG ODN. It functions as a potent agonist of Toll-like receptor 9 (TLR9), an endosomal receptor that recognizes pathogen-associated molecular patterns (PAMPs) in the form of DNA. Upon activation, CpG B344 triggers a signaling cascade involving the adapter protein MyD88 and the NF-κB pathway, leading to the maturation of antigen-presenting cells and the secretion of pro-inflammatory cytokines such as IL-12 and IFN-γ. While CpG ODNs are broadly studied across species, the B344 sequence (typically an 18-mer consisting of TCG repeats) is particularly prominent in veterinary research. It is utilized as an immunomodulator and vaccine adjuvant to enhance protective immunity against avian pathogens, including avian influenza virus, *Salmonella enteritidis*, and infectious bursal disease virus.

Other names

CpG ODN B344