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CPV-164

Development stage: Preclinical
Lead developer: University of Puerto Rico
Modality: Small Molecules
Administration: Parenteral

Overview

CPV-164 is a small molecule cyclic thiosulfinate derivative developed by the University of Puerto Rico. It acts as an inhibitor of thioredoxin reductase 1 (TrxR1), an enzyme that is overexpressed in various cancers and plays a critical role in cellular redox regulation, antioxidant defense, cell proliferation, and apoptosis. In preclinical in vitro studies, CPV-164 demonstrated significant cytotoxic activity and inhibition of cell proliferation against a panel of breast cancer cell lines.

Targets

TXNRD1 (Thioredoxin reductase 1)

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