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CPX-351 (daunorubicin + cytarabine) (Jazz Pharmaceuticals plc, 041b4e)
- Development stage
- Phase 4
- Lead developer
- Jazz Pharmaceuticals
- Modality
- Small Molecules, Lipid-based Nanoparticles → Nanoparticles → Drug Delivery Systems
- Administration
- Intravenous
01
Overview
CPX-351 (Vyxeos) is a liposomal encapsulation of the antineoplastic agents cytarabine and daunorubicin, maintained at a fixed 5:1 molar ratio. This formulation is designed to deliver the two drugs synergistically to leukemia cells while limiting systemic exposure and toxicity. Cytarabine, a pyrimidine analog, inhibits DNA polymerase and DNA synthesis, while daunorubicin, an anthracycline, intercalates into DNA and inhibits topoisomerase II. CPX-351 is FDA-approved for the treatment of adults and pediatric patients (1 year and older) with newly-diagnosed therapy-related acute myeloid leukemia (t-AML) or AML with myelodysplasia-related changes (AML-MRC). It is also being investigated for use in higher-risk myelodysplastic syndromes (MDS).
- Brand names
- Vyxeos
- Other names
- liposomal cytarabine and daunorubicindaunorubicin-cytarabine liposome
02
Targets
DNADNA polymerase familyTOP2A (DNA topoisomerase II)
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